(R)-(+)-3-Chloro-1,2-propanediol acetonide
(R)-3-chloro-1,2-propanediol acetonide
CAS: 57044-24-3
Molecular Formula: C6H11ClO2
(R)-(+)-3-Chloro-1,2-propanediol acetonide - Names and Identifiers
(R)-(+)-3-Chloro-1,2-propanediol acetonide - Physico-chemical Properties
| Molecular Formula | C6H11ClO2 |
| Molar Mass | 150.6 |
| Density | 1.103g/mLat 25°C(lit.) |
| Boling Point | 63°C37mm Hg(lit.) |
| Specific Rotation(α) | 42.1 º (NEAT) |
| Flash Point | 123°F |
| Appearance | clear liquid |
| Color | Colorless to Almost colorless |
| BRN | 4654188 |
| Refractive Index | n20/D 1.434(lit.) |
(R)-(+)-3-Chloro-1,2-propanediol acetonide - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R10 - Flammable R41 - Risk of serious damage to eyes |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | UN 1993 3/PG 3 |
| WGK Germany | 3 |
| HS Code | 29329990 |
| Hazard Class | 3 |
| Packing Group | III |
(R)-(+)-3-Chloro-1,2-propanediol acetonide - Introduction
(R)-3-chloro-1,2-propanediol acetonide, abbreviated as (R)-3-CPA, is an organic compound. Its molecular formula is C5H9ClO2 and its molecular weight is 136.58g/mol.
In terms of properties,(R)-3-CPA is a colorless to light yellow liquid with a pungent odor at normal temperature and pressure. It is soluble in most organic solvents such as ethanol, ethers and chlorinated hydrocarbons.
(R)-3-CPA is widely used. It is often used in asymmetric synthesis reactions in organic synthesis and can be used as a precursor of chiral reagents and catalysts. In addition, it can also be used as an intermediate in the pharmaceutical field for the synthesis of some drugs.
The preparation of (R)-3-CPA can be accomplished by reacting propylene glycol with hydrogen chloride. The reaction conditions can be optimized for high yield and selectivity by adjusting the catalyst, solvent and temperature.
Regarding safety information,(R)-3-CPA is a hazardous chemical that is irritating and corrosive. Contact with skin and eyes can cause irritation and may result in chemical burns. Wear protective gloves, glasses and protective clothing during handling and storage, and ensure that the operation is carried out under well-ventilated conditions. If contact with skin or eyes occurs, rinse immediately with plenty of water and seek medical help.
In addition,(R)-3-CPA may also cause pollution to water bodies and the environment, so appropriate treatment and disposal measures need to be taken to avoid damage to the environment. When using and disposing, please follow the relevant regulations and safe operation procedures.
In terms of properties,(R)-3-CPA is a colorless to light yellow liquid with a pungent odor at normal temperature and pressure. It is soluble in most organic solvents such as ethanol, ethers and chlorinated hydrocarbons.
(R)-3-CPA is widely used. It is often used in asymmetric synthesis reactions in organic synthesis and can be used as a precursor of chiral reagents and catalysts. In addition, it can also be used as an intermediate in the pharmaceutical field for the synthesis of some drugs.
The preparation of (R)-3-CPA can be accomplished by reacting propylene glycol with hydrogen chloride. The reaction conditions can be optimized for high yield and selectivity by adjusting the catalyst, solvent and temperature.
Regarding safety information,(R)-3-CPA is a hazardous chemical that is irritating and corrosive. Contact with skin and eyes can cause irritation and may result in chemical burns. Wear protective gloves, glasses and protective clothing during handling and storage, and ensure that the operation is carried out under well-ventilated conditions. If contact with skin or eyes occurs, rinse immediately with plenty of water and seek medical help.
In addition,(R)-3-CPA may also cause pollution to water bodies and the environment, so appropriate treatment and disposal measures need to be taken to avoid damage to the environment. When using and disposing, please follow the relevant regulations and safe operation procedures.
Last Update：2024-04-10 22:30:50
